![]() ![]() While stress deleteriously impacts humans worldwide and attacks all segments of societies at this moment in human history, it is disproportionately devastating to individuals in vulnerable situations such as pregnant women. Major depressive disorder (MDD) affects millions of people globally who have been subject to stress and trauma at some times of their lives. ![]() ![]() Intergenerational trauma increases lifetime susceptibility to depression and is a major risk factor for developing multiple neuropsychiatric disorders such as post-traumatic stress disorder (PTSD), autism spectrum disorder (ASD), and schizophrenia 1, 2, 3, 4. Most strikingly, early pharmacological interventions with acetyl-L-carnitine (ALCAR) supplementation produced long-lasting protection against intergenerational trauma-induced depression. Bioinformatic analyses revealed stress- and hypoxia-response metabolic pathways in the neonates, which produced long-lasting alterations in mitochondrial energy metabolism and epigenetic processes (DNA and chromatin modifications). Striking increases in the mitochondrial hypoxia marker and epigenetic modifier 2-hydroxyglutaric acid in the brains of neonates and adults exposed prenatally to trauma indicated mitochondrial dysfunction and epigenetic mechanisms. The behavioral deficits were associated with profound changes in the brain metabotranscriptome. Good caregiving by normal mothers did not reverse prenatal trauma-induced behaviors, indicating a two-hit stress mechanism comprising both in-utero abnormalities and early-life poor parenting. Normal pups raised by traumatized mothers exhibited similar behavioral deficits to those induced in pups raised by their biological traumatized mothers. Here, we demonstrate that trauma exposure during pregnancy induces in mouse offspring social deficits and depressive-like behavior. Whether intergenerational trauma transmission is a consequence of in-utero neurodevelopmental disruptions versus early-life mother–infant interaction is unknown. Intergenerational trauma increases lifetime susceptibility to depression and other psychiatric disorders. ![]()
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![]() In the long-term care system, the Cognitive Performance Scale (CPS), originally developed using data from the Minimum Data Set (MDS) assessment ( 1), is a widely used tool. This enabled continuity in repeated assessment with different tools and improved comparability of cognitive scores generated from different tools from diverse populations and research cohorts.Īssessing cognition in the aging population is necessary to understand the magnitude of loss in cognitive performance. The linking functions revealed the floor and ceiling effects that exist for the different scales, with CPS and CPS2 measuring more-severe cognitive impairment while the MoCA 5-min was better suited to measure mild impairment.Ĭonclusions: We provided score conversions between MoCA 5-min and CPS/CPS2 within a large cohort of Hong Kong older adults with mild physical or cognitive impairment. At the higher end, a CPS score of 3 (moderately impaired) and a CPS2 score of 5 (moderately impaired Level-2) corresponded to MoCA 5-min scores of 0 and 1, respectively. ![]() A CPS or CPS2 score of 0 (intact cognition) corresponds to MoCA 5-min scores of 24 and 25, respectively. Results: 3,543 participants had valid data on both scales 66% were female and their average age was 78.9 years (SD = 8.2). We performed equipercentile linking with bivariate log-linear smoothing to establish equivalent scores between the two scales. Each participant's cognitive performance was assessed using CPS, CPS Version 2 (CPS2), and MoCA 5-min. The program used the interRAI-Check Up instrument for needs assessment and service matching between 20. Methods: We included individual-level data from persons who participated in a home- and community-based care program for older people with mild impairment in Hong Kong. This study linked scores from the Montreal Cognitive Assessment-5 min (MoCA 5-min) to the interRAI cognitive Performance Scale (CPS), commonly adopted tools in clinical and long-term care settings, respectively. 2Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong, SAR Chinaīackground: Bridging scores generated from different cognitive assessment tools is necessary to efficiently track changes in cognition across the continuum of care. ![]() 2/18/2024 0 Comments Cpanel download free mac![]() ![]() Our Plugins RepositoryĬontains a list of plugins and instructions on how to install them and keep them up-to-date. ![]() Roundcube uses Composer to manage add-ons and dependencies.
![]() You can read the article above to know which are the best bass booster apps in the market. Plenty of apps are in the market for this purpose however, the best one among them is Boom3d. What is the best bass booster app for PC? On your Windows PC, go to the Volume Mixer option on your Taskbar and then click the Enhancements tab, and choose the Bass Booster option to boost the bass. I hope the above article will help you choose the best bass booster for your PC and let you enjoy the music in high bass. The boosters will not only enhance the overall experience of your music listening but also provide a clear and crisp sound. Whether you are a DJ, or karaoke singer, or love bass in your music, you can utilize the above-mentioned bass booster for PC to boost the bass to your song collection. Using the best free bass booster for PC can alter the way the music sounds in real-time and enhance the overall music listening experience. Right-click on it and select Update driver. Supports multiple media formats including FLAC, WAV, MOV, and many othersĬonclusion On Bass Booster For Windows 11, 10 PC Alternatively, you can go to Device Manager (Windows key + X) and double-click on ‘Audio inputs and outputs’ to expand it.Loaded with various video and audio tweaking options.The screen capture feature allows you to take video screen shorts directly from the player.Using this tool you can change and boost the bass as per your needs. ![]() Some of its extraordinary features are a GOM remote, 360-degree video player, subtitle finder, VR video support, and many others. Despite being free it offers professional-level features. It comes in both 32-bit and 64-bit downloads.GOM Player is a popular media player software for Windows which also helps you boost the bass of the music. Previous versions of the OS shouldn't be a problem with Windows 8 and Windows 7 having been tested. It can run on a PC with Windows 11 or Windows 10. Is Sound Booster for Windows 10 or Windows 11? The Sound Booster 1.12.533 demo is available to all software users as a free download with potential restrictions and is not necessarily the full version of this software. This download is licensed as shareware for the Windows operating system from components and can be used as a free trial until the trial period ends (after an unspecified number of days).
2/18/2024 0 Comments Free online word connect game![]() ![]() The nice and clean BOARD provides a delightful backdrop for your word-searching journey.īest of all, Word Cross is entirely FREE for all players! Train your word search skills while enjoying the simplicity of the game. Stay tuned for customizable themes to personalize your gaming experience. The addiction is real-play once, and you won't be able to resist the thrill! Word Cross offers more than just a game it's a brain-challenging adventure! Collect coins by finding words with bonuses and use them to get hints through purchases or by watching videos. Looking for a fun and addictive game to keep you entertained Word Connect is the choice for you Play Word Connect game online for free at. Need a hint? Tap the "Hints" button for clues, or shake things up with the "Shuffle" button to rearrange the letters. The handy and easy-to-master gameplay makes it accessible to players of all skill levels. Word Connect is made with html5 technology, and its available on PC and Mobile web. Word Connect -Wordscapes is a popular word puzzle game that combines elements of word searching, anagrams, and crosswords. Is there any better than discover the world while learning new words and improving your vocabulary Word Connect is free and unique word game for adults. This game has received 14450 plays and 77 of game players have upvoted this game. Word Connect Games Welcome to the exciting world of Word Connect Games These games are all about connecting letters to form words, testing your vocabulary and puzzle-solving skills in a fun and engaging way. Word Connect Online is in the category of Brain. Swipe letters effortlessly to uncover hidden words both horizontally and vertically. Word Connect is an online game that you can play in modern browsers for free. This addictive word game will keep you entertained for hours, with a clean and fresh BOARD UI that is visually appealing. Immerse yourself in the excitement of over 1,000 challenges that start easy and quickly become a test of your word prowess. Word Cross adventure for a thrilling and fresh crossword puzzle experience!.Įmbark on a Word Cross adventure for a thrilling and fresh crossword puzzle experience! ![]() 2/18/2024 0 Comments Fat tire mini bike kits![]() ![]() This type of conversion kit mimics what you see on complete e-bikes. ![]() Integrating a battery into the wheel or mounting it on the rear rack tends to shift all the weight to the back wheel, resulting in unforeseen wheelies when you apply too much power. You can also mount a separate battery on the frame, although this is not a necessity. But if your bike already has a hub gear, it will have to be replaced with a cassette and derailleur. The general rule of thumb is that you’ll need the frame to be stronger than a road bike's if you want to install a front-wheel motor.Ī back-wheel motor is more suitable for off-road biking because of improved traction. You also want to consider the strength of the fork and make sure that it can cope with the torque from the electric motor. On the other hand, steering becomes heavy when the whole weight sits on the front wheel. You may also find a battery on the hub or have it mounted somewhere else.įor a battery that is mounted separately, replacing the front wheel will be preferable for road biking given that the weight of the kit will be distributed evenly across your bike. ![]() In this case, the front or rear wheel on your current bike is replaced with a special wheel that features a hub and gearing. The most common type of conversion kit you’ll find. The following e-bike conversion kits are usually available for this purpose: E-bike Wheels There are various ways you can choose to power your bike using an electric motor. FAQ What are the different types of e-bike conversion kits? ![]() 2/18/2024 0 Comments Fall wedge dress sandals![]() ![]() One of the most common varieties of wedge sandals is the Espadrille nude wedges sandals. Also, their colors are present in ranges. Aside from elongating your legs in short panties, they help to elevate your outfit. They go well with a range of female casual wear and are appropriate for different events. The ankle strap wedges are casual but are not limited if you are styling them. Combined with this is the sling back strap provided for extra security. Just as the name suggests, these heels come with a fastener strap around the ankle to keep your legs from swerving around they keep your feet firm in the shoe and maintain the shape. Ankle Strap WedgesĪnkle Strap wedges are another type of women's wedge low heel sandals you can find in fashion stores and outlets. While the season drifts towards summer, a skirt with these shoes won’t look bad. In winter, you can style a pair of platform closed toe wedges with your sundresses. The dual feature that encompasses these shoes makes them appropriate to wear to casual and formal events in a different season of the year. The Platform wedges sandals can be casual with different styling or perhaps shifted to a less-formal way if you deem it fit to change the outer look. Platform wedge heels have a relatively balanced construction, unlike most other shoe straps that get stuffy when fastened to the legs. The straps can be worn around your ankles or extended and worn straight up your legs. ![]() Like most other wedge heels sandals, they include an ankle strap that varies in length and elongation. The platform wedge heels are perfect for women who wish to show off their fashion in a simple way. These wedge ankle strap sandals are one of the most popular varieties of wedge open toe sandals. The trio of fashion, comfort, and flexibility accustomed to the shoes make them one of the top options in female shoe rack collections for those who know their styling. These shoes found their way to the fashion world in the early Greece days and have continued to maintain a spot in the fashion cycle several years after. Wedge heel sandals are female footwear designed to replicate the utmost fashion standards in flats and heeled shoes. You'll want to grab a pair for every event in your life. Pick a pair of closed toe wedges for work or a night out with the gang. Inspire looks of jealousy from your closest friends. With Dream Pairs' versatile range, you'll always have a pair ready for wherever you go. For a more conservative look, you can choose our low heel wedge which comes in a plethora of colors including black, white, and nude. They are easy to strap on with our lightweight ankle strap and come in all sorts of styles. Look no further than our variety of nude wedges for an extra boost in life. ![]() Whether it's platform wedge heels sandals or closed-toe flat wedge sandals, Dream Pairs has you covered. Ease your mind with a pair of our wedge sandals. You'll never have to worry about accidentally tripping or breaking a heel. With our cute, stylish, and trend-setting wedges, you'll be able to live how you want. You don't have to sacrifice comfort to look amazing. Related Collection Searches Heel Sandals White Wedge Sandals Silver Low Heel Wedge Sandals Flat Sandals T-Strap Sandals Comfort Sandals Ankle Strap Sandals Flat Sandals Strappy Wedge Sandals Athletic Sandals Slip on Wedge Sandals Chunky Platform Sandals White Flat Sandals Comfort Walking Sandals Gold Heel Sandals Platform Sandals Wedges: The Perfect Balance of Height and Comfort ![]() 2/17/2024 0 Comments Text art copy and paste twitch![]() ![]() What can I do about this?!?!? Was I in the wrong for expressing my gender and identity?!? (Only serious answers, please). Copy the result with one click and start sharing art in Twitch. Upload an image and itll automatically be turned into ASCII art. Convert an image file into ASCII art (text art) with this tool. I was kicked out of the class by the dreamphobic teacher, and today the school principal called me and my parents to a meeting and told us that I may be expelled from the school, merely from expressing my gender and sexuality. Character width (optimal Twitch Chat width: 30) click to copypasta. It honestly were the greatest 10 minutes of my life, until my libido reached its climax and I let out a gigaload of cum for Daddy Dream that landed on the phone's screen and ended up turning on the mic and camera, and everyone stared horrified at me, screaming at the sight of my honest and earnest love expression to Dream. I immediately ripped off all my clothes and started furiously stroking my fully erect penis for a good 10 min, even sticking my Dream body pillow up my rectum, imagining that it was Daddy Dream penetrating me while whistling his hit song 'Mask'. The whistling stopped for a couple of minutes until I started hearing it again, and then I knew exactly what it was: it was the chorus of Dream's hit song 'Mask'. Note that this technically isn't gorilla ASCII art, since it uses general Unicode characters other than the simple ASCII ones, but people tend to use. So I was having online classes with my camera turned off when I started hearing a little whistle from one of the students in the background that seemed very familiar, but I couldn't put my finger on it. Don't forget to click the spacesunderscores button to fill the white space with underscore characters so that when you paste it somewhere, it doesn't collapse all the spaces. Because of its association with the sex position and resulting meme, "69" has become known as "the sex number" in certain communities. This means to sarcastically imply that the reference to the sex position was intentional. In reference to the sex position, "69" has become an internet meme, where users will respond to any occurrence of the number with the word "nice" and draw specific attention to it. For safer oral sex, use a condom to cover the penis, or a Sheer Glyde dam, cut-open condom, or plastic wrap to cover the vulva or anus. ![]() Oral sex is generally less risky for these infections than unprotected vaginal or anal sex, but there is still some risk. These infections include gonorrhea, syphilis, chancroid, herpes, hepatitis B, cytomegalovirus, human papilloma virus (HPV), herpes, and, rarely, HIV and chlamydia. But it can pass on infections, whether the person is giving or receiving genital stimulation. Oral sex on a woman is called “cunnilingus.” On a man it’s called “fellatio.” Anyone - girl or guy - can give or receive oral sex as long as she or he is comfortable with it and wants to engage in in oral sex. Oral sex is when people use their mouths to stimulate another person’s genitals. It's funny because 69ing, or doing 69, is sharing oral sex with your partner in other words, it’s giving and receiving oral sex at the same time. ![]() 2/17/2024 0 Comments Microwave vanilla fudge recipe![]() an 8 by 4-inch loaf pan if you like to cut slices of fudge.an 8-inch or 9-inch square pan if you prefer thinner fudge squares or rectangles.a 6-inch square pan if you prefer thick fudge squares.non-stick metal, glass, ceramic, aluminum, tin foil, or even silicone pans.You can find these milk chocolate bars, callets, and chips from amazon (commission earned for sales). NOTE: Finely chop, grate, or shave chocolate bars in order for the chocolate to melt more quickly. ![]() Of the grocery store brands, I prefer Kroger Private Selection Milk Chocolate Chips but have also enjoyed making fudge using Hershey's Milk Chocolate Chips and Ghirardelli Milk Chocolate Chips.Callebaut makes wonderful milk chocolate too which is available in callets (large chips) and smaller quantities.If you love milk chocolate and plan to make a lot of fudge, then purchasing one of these bars will be totally worth it. It is available in 10-pound bars or 50-pound cases. This is the milk chocolate I use for all of my candy-making.It has a lovely delicate chocolate flavor with slight caramel notes. I personally love using Peter's Ultra Milk Chocolate.Milk Chocolate is sweet and creamy and has a mild chocolate flavor.Pure milk chocolate will have cocoa butter and some form of milk listed in the ingredients.pure milk chocolate bars, blocks, or chips.You can read our Easy Fudge Recipe FAQ page for detailed instructions on making homemade fudge. Just like that recipe, this easy fudge recipe uses just two ingredients: milk chocolate and sweetened condensed milk.īefore we get to this sweetened condensed milk fudge recipe, let me give you some details about making easy fudge. I prefer semi-sweet chocolate over bittersweet chocolate in most recipes and particularly in our Dark Chocolate Fudge Recipe. I haven't gone completely to the dark side, though. It's just recently that I have developed a taste for the more strongly flavored dark chocolate. I have to admit that it wasn't that long ago that I preferred the lighter-flavored chocolate too. This delicately flavored chocolate fudge is a favorite with kids who prefer things a little bit sweeter and slightly more mellow in flavor. If you prefer lightly colored, rich, and creamy, milk chocolate over the more robust flavored dark chocolate this Milk Chocolate Fudge is for you. It's also incredibly easy to make in the microwave or on the stove using just 2 ingredients. Spread over chilled fudge.Smooth and creamy and slightly sweet Milk Chocolate Fudge is decadently rich and amazingly good. For glaze, melt 1/2 cup peanut butter chips with 1/2 cup heavy cream. CHOCOLATE PEANUT BUTTER CHIP GLAZED FUDGE: FOLLOW above recipe using 3/4 cup peanut butter chips instead of nuts.MILK CHOCOLATE FUDGE: OMIT 1 cup semi-sweet chocolate chips.CREAMY DARK CHOCOLATE FUDGE: MELT 2 cups miniature marshmallows with chocolate chips and sweetened condensed milk.Remove pie plate from water bath and cool, uncovered. Check water level and add additional, if necessary, then continue to bake 45 minutes more, or until milk is thick and brown. ![]() Set plate in a roasting pan and add enough hot water to pan to reach halfway up pie plate. ![]() Pour the contents of 1 (14-ounce) can of Eagle Brand ® sweetened condensed milk into a 9-inch deep-dish pie plate and cover tightly with foil.
2/17/2024 0 Comments Free script font glyphs![]() ![]() Using any of these fonts can up your typography game and make any project a hundred times more enjoyable to work on. I hope this will make searching for the right font for those t-shirts, farmhouse signs, or mugs intended to sell easier. Hands down, one of the great sites that allows you to use fonts for commercial use at no charge is Font Bundles. I looked and sifted through font sites to find the fonts that can be used both for personal and commercial projects. So you are limited by the number of projects you can use these fonts for and also left with a barebone version of otherwise a feature-rich font with tons of lovely extras. But in many cases, free fonts that you find online come with a personal use license and can only be downloaded as a demo version with no glyphs or additional characters support. The number of fonts available to designers and crafters is infinite, so is the amount of time you spend looking for that perfect fit. I know my way around typography and the best classic typefaces that would suffice for any design, but new fonts keep inspiring me at every turn. ![]() ![]() Discovering the power of fonts and learning all about tails, stems, and ears that letters are made of was the best takeaway from my years in the graphic design program. The most important thing I’ve learned from my experience as a graphic designer is that typography alone can make or break a design. ![]() |
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